Fritsche Lab Fritsche Lab

Research

Research

We study whether findings from genomic, clinical, and patient-reported data are consistent across populations and health systems.

A result can look convincing in one dataset but fail to replicate in another. Across our four programs, we develop methods, compare results across datasets, and publish resources to help explain those differences.

Research programs

Polygenic risk

Evaluating Polygenic Risk Scores at Scale

We test published risk scores in large biobanks and release the results, methods, mappings, and score files.

  • Polygenic risk scores
  • Biobank evaluation
  • Reproducibility

Mental health

Precision Mental Health

We study mental health treatment response using genetic, clinical, and patient-reported data.

  • COMPASS
  • Treatment response
  • Patient-reported outcomes

Pain research

Pain Genetics and Phenotyping

We study the genetic basis of pain and define pain phenotypes using clinical records, imaging, and patient-reported data.

  • Pain genetics
  • Pain phenotyping
  • Statistical genetics

Collaborative work

Current work includes the PRSweb resource, the COMPASS precision mental health study, and the U-M HEAL PAIN T90/R90 training program.

Precision mental health

Active

COMPASS

COMPASS studies how genetic, clinical, and patient-reported information relates to mental health treatment response. Its full name is Comprehensive Mobile Precision Approach for Scalable Solutions in Mental Health Treatment.

Amy Bohnert, Srijan Sen, and Lars Fritsche are the principal investigators. Lars leads the genetics and EHR data work, including polygenic scores, pharmacogenetics, and analyses of diagnoses and medication histories.

National Institute of Mental Health
U01 · U01MH136025 · 2024-present

Pain research training

Active

U-M HEAL PAIN Cohort Program

The U-M HEAL PAIN T90/R90 Cohort Program provides research training and mentoring for early-career chronic pain researchers.

Daniel Clauw, Kelley McLain Kidwell, and Jenna Wiens are the principal investigators.

NIH HEAL Initiative
T90/R90 · T90DE034663 / R90DE034663 · 2024-2029 for T90/R90

Public research resource

Current collection with archived releases

PRSweb Research Portals

PRSweb provides polygenic risk score evaluations, phenome-wide association results, and downloadable score files.