Lab Head
Lars Fritsche, PhD
Lars works with collaborators to combine genetic, clinical, patient-reported, and mobile data in studies of treatment response and disease risk.
Collaboration
Most of Lars’s collaborations start with a clinical or scientific question and different types of data that do not line up neatly. He helps teams define electronic health record (EHR) phenotypes, combine genetic and clinical data, choose an analysis strategy, and test whether findings hold up in other cohorts and populations. His expertise includes genome-wide association studies (GWAS), polygenic scores, pharmacogenetics, longitudinal prediction, and reproducible analysis workflows.
He is especially interested in projects that connect genetics with diagnoses, medications, patient reports, or mobile data, and in analyses that can become useful tools or shared resources for other researchers.
Current work
Lars is one of the principal investigators on COMPASS and leads its genetics and EHR data work. This includes polygenic scores, pharmacogenetics, and health histories based on diagnosis and medication records. He also contributes to pain studies that combine EHR phenotypes with genetics, imaging, and patient reports. He leads PRSweb, a collection of public resources for evaluating and sharing polygenic risk scores.
Outside the lab
In his free time, Lars rows with the Ann Arbor Rowing Club. He is an avid sculler, volunteers as a sculling instructor, and serves on the club’s board as secretary and membership chair.